From artificial red blood cells, oxygen carriers, and oxygen therapeutics to artificial cells, nanomedicine, and beyond
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چکیده
منابع مشابه
Blood substitutes Artificial oxygen carriers: perfluorocarbon emulsions
Perfluorocarbon emulsions are being clinically evaluated as artificial oxygen carriers to reduce allogeneic blood transfusions or to improve tissue oxygenation. Perfluorocarbon emulsions are efficacious in animal experiments, and in humans they are well tolerated and at least as successful to reverse physiologic transfusion triggers than autologous blood. Perfluorocarbon emulsions may be used i...
متن کاملArtificial oxygen carriers as a possible alternative to red cells in clinical practice.
Fluid resuscitation is intended to eliminate microcirculatory disorders and restore adequate tissue oxygenation. The safety limits for a restrictive transfusion policy are given by patients' individual tolerance of acute normovolemic anemia. Artificial oxygen carriers based on perfluorocarbon or hemoglobin are attractive alternatives to allogenic red blood cells. There are many risks involved i...
متن کاملArtificial oxygen carriers as red blood cell substitutes: a selected review and current status.
Two distinct approaches are being explored in red blood cell substitute (RCS) development: hemoglobin-based oxygen carriers (HBOCs) and perfluorocarbon-based oxygen carriers (PFBOCs). HBOCs are based on intra- and/or intermolecularly "engineered" human or animal hemoglobins (Hbs), optimized for O2 delivery and longer intravascular circulation. Some are currently being evaluated in Phase II/III ...
متن کاملDevelopmental Trend of Artificial Blood ( Artificial Red Blood Cells )
Regarding research on artificial blood, the “Field of Artificial Blood Development” was inaugurated in 1997, supported by the Ministry of Health and Welfare Grant-in-Aid for Health Science Research, for intensive research activities in the three sub-fields, i.e., artificial red blood cells, artificial platelets, and artificial antibodies. Developed by molecular assembling technology, artificial...
متن کاملArtificial oxygen carriers: a new future?
Despite the fact that allogeneic red blood cell (RBC) transfusions can be life-saving in exsanguinating trauma patients, many adverse events impacting patient outcome have documented [1]. Therefore, artificial oxygen carriers were initially been developed as “blood substitutes” in the 1980s and 1990s. Artificial oxygen carriers can be grouped into hemoglobin-based oxygen carriers (HBOCs) and pe...
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ژورنال
عنوان ژورنال: Artificial Cells, Blood Substitutes, and Biotechnology
سال: 2012
ISSN: 1073-1199,1532-4184
DOI: 10.3109/10731199.2012.662408